The park is situated in the tourist region of the Red Sea Riviera, located 12 km from the city of Sharm El Sheikh. The park spans an area of 480 km², including 135 km² of surface land area and 345 km² area over water. Marsa Bareika is a small bay inlet in Ras Mohammed, and Marsa Ghozlani is a very small inlet located across from the park visitors center.

Winch parts visible on the wreck of the SS Thistlegorm, which sunk off the coast of Ras Muhammad

Ras Mohammad encompasses two islands, Tiran and Sanafir. Tiran Island is located approximately 6 km offshore from the Sinai Peninsula. Underwater caves formed as the result of earthquakes are located in Ras Mohammad.

About 0.9 hectare of mangrove forest cover a 1.16 km shallow channel at the southernmost end of Ras Mohammad peninsula. Near the mangrove and approximately 150 m inland, there are open cracks in the land, caused by earthquakes. One of the cracks is approximately 40 m length and 0.20−1.5 m in width. Within the cracks, there are pools of water, some with a depth of over 14 m.

The inland area includes a diversity of desert habitats such as mountains and wadis, gravel and coastal mud plains and sand dunes. The area also plays a role in bird migration, serving as a place of rest and nourishment.